Publications

2024

Consecutive palmitoylation and phosphorylation orchestrates NLRP3 membrane trafficking and inflammasome activation.

Ni L*, Fei C*, Fan Y*, Dang F*., et al. Mol. Cell. 84: 1-18 (2024).

Reciprocal antagonism of PIN1-APC/C^CDH1 governs mitotic protein stability and cell cycle entry.

Ke S*, Dang F*, Wang L*, Chen JY*, et al. Nat. Commun. 15(1): 3220 (2024).

The palmitoylation of gasdermin D directs its membrane translocation and pore formation during pyroptosis.

Balasubramanian A, Hsu AY, Ghimire L, Tahir M, Devant P, Fontana P, Du G, Liu X, Dang F, et al. Sci. Immunol. 9(94): eadn1452. doi: 10.1126/sciimmunol.adn1452 (2024).

MYC induces CDK4/6 inhibitors resistance by promoting pRB1 degradation.

Ma J, Li L, Ma B, Liu T, Wang Z, Ye Q, Peng Y, Wang B, Chen Y, Xu S, Wang K, Dang F, et al. Nat. Commun. 15(1): 1871 (2024).

2023

USP2 inhibition prevents infection with ACE2-dependent coronaviruses in vitro and is protective against SARS-CoV-2 in mice.

Dang F*, Bai L*, Dong J*, Hu X*, et al. Sci. Transl. Med. 15(725): eadh7668. doi: 10.1126/scitranslmed.adh7668 (2023).

Metabolic orchestration of cell death and inflammation through AMPK-mediated phosphorylation of RIPK1.

Zhang T, Xu D, Trefts E, Lv M, Liu J, Liu M, Chu C, Wang M, Wang H, Meng H, Liu H, Zhuang Y, Xie X, Dang F, et al. Science, 380(6652): 1372-1380 (2023).

Oxygen-sensitive prolyl hydroxylation of RIPK1 suppresses its activation.

Zhang T, Xu D, Liu J, Wang M, Duan L, Lv M, Meng H, Liu M, Zhuang Y, Lee Y, Wang H, Shi L, Guo R, Liu H, Erickson E, Wang Y, Yu W, Dang F, et al. Nat. Cell Biol., 25(7): 950-962 (2023).

An intrinsic connection between COVID-19 and aging.

Wang J, Wei JCJ, Dang F, Inuzuka H. Acta Materia Medica 2 (3), 342-346

2022

Targeting the acetylation signaling pathway in cancer therapy.

Dang F, Wei W. Semin. Cancer Biol. 85: 209-218, doi: 10.1016/j.semcancer.2021.03.001 (2022).

2021

Inhibition of CK1ε potentiates the therapeutic efficacy of CDK4/6 inhibitor in breast cancer.

Dang F*, Nie L*, Zhou J*, et al. Nat. Commun. 12(1): 5386 (2021).

Ubiquitin Signaling in Cell-cycle Control and Tumorigenesis.

Dang F, Nie L, Wei W. Cell Death & Differ. 28(2): 427-438 (2021).

PCAF and SIRT1 modulate βTrCP1 protein stability in an acetylation-dependent manner.

Dang F*, Jiang C*, Zhang T, Inuzuka H, Wei W. J Genet Genomics. 48(7): 652-655 (2021).

2019

PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage.

Zhang J*, Lee YR*, Dang F*, Gan W, Menon AV, Katon JM, Hsu CH, Asara JM, Tibarewal P, Leslie NR, Shi Y, Pandolfi PP, Wei W. Cancer Discov. 9(9): 1306-1323 (2019).

The Circadian Protein Period2 Suppresses mTORC1 Activity via Recruiting Tsc1 to mTORC1 Complex.

Wu R, Dang F, Li P, Wang P, Xu Q, Liu Z, Li Y, Wu Y, Chen Y, Liu Y. Cell Metab. 29(3): 653-667 (2019).

SPOP Promotes Nanog Destruction to Suppress Stem Cell Traits and Prostate Cancer Progression.

Zhang J, Chen M, Zhu Y, Dai X, Dang F, et al. Dev. Cell, 48(3): 329-344 (2019).

2018

Biochemical Aspects of PD-L1 Regulation in Cancer Immunotherapy.

Zhang J*, Dang F*, Ren J, Wei W. Trends Biochem. Sci. 43(12): 1014-1032 (2018).

2016

Insulin post-transcriptionall modulates Bmal1 protein to affect hepatic circadian clock.

Dang F*, Sun X*, Ma X, Wu R, Zhang D, Chen Y, Xu Q, Wu Y, Liu Y. Nat. Commun. 7: 12696 (2016).

Fasting and Feeding Signals Control the Oscillatory Expression of Angptl8 to Modulate Lipid Metabolism.

Dang F, Wu R, Wang P, Wu Y, Azam MS, Xu Q, Chen Y, Liu Y. Sci. Rep. 6: 36926 (2016).

2015

Glucagon-CREB/CRTC2 signaling cascade regulates hepatic BMAL1 protein.

Sun X, Dang F, Zhang D, Yuan Y, Zhang C, Wu Y, Wang Y, Liu Y. J. Biol. Chem., 290(4): 2189-2197 (2015).

(* Equal contribution)